Last edited by Jugar
Sunday, May 3, 2020 | History

2 edition of Apoptosis in cardiac biology found in the catalog.

Apoptosis in cardiac biology

Apoptosis in cardiac biology

  • 123 Want to read
  • 27 Currently reading

Published by Kluwer Academic in Boston .
Written in English

    Subjects:
  • Apoptosis.,
  • Heart -- Cytopathology.,
  • Heart cells.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Heribert Schunkert, G.A.J. Riegger.
    SeriesBasic science for the cardiologist -- 5.
    ContributionsRiegger, G. A. J., Schunkert, Heribert.
    Classifications
    LC ClassificationsQH671 A66 2000
    The Physical Object
    Paginationxiv, 353 p. :
    Number of Pages353
    ID Numbers
    Open LibraryOL22031308M
    ISBN 100792386485

      The very fact that myocyte apoptosis occurs in chronic heart failure, albeit at a pace yet to be defined and with a magnitude yet uncertain, supports the concept of ongoing loss of functional cardiac units. Cardiomyocyte apoptosis was identified in dogs with heart failure produced by multiple sequential intracoronary microembolization ; a model Cited by: Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly regulated process, pharmacological intervention of apoptosis pathways may represent a promising therapeutic strategy for a number of cardiovascular diseases and disorders including myocardial infarction, ischemia Cited by:

      Introduction. Apoptosis has previously been shown to play an essential role in the pathogenesis of heart dysfunctions related to ischaemia/reperfusion (I/R), pressure overload, and chronic heart failure. 1 Increased cardiomyocyte apoptosis results in contractile tissue loss, compensatory hypertrophy, and reparative fibrosis, all contributive to the development of cardiovascular diseases. 1 Cited by: AGE-induced cardiac apoptosis belongs to the intrinsic apoptosis pathway, as demonstrated in our previous study. AGE upregulated p-PKCδ and apoptosis-related markers, including cleaved caspase-9, cleaved caspase-3, and cytochrome c, and downregulated p-AKT.

    Apoptosis, also called programmed cell death, in biology, a mechanism that allows cells to self-destruct when stimulated by the appropriate trigger. Apoptosis can be triggered by mild cellular injury and by various factors internal or external to the cell; the damaged cells are then disposed of . The Basic Biology of Apoptosis and Its Implications for Cardiac Function and Viability Guro Valen, MD, PhD Crafoord Laboratory of Experimental Surgery, Karolinska Hospital, Stockholm, Sweden Apoptosis or programed cell death is a continuous pro-cess of destruction of nonfunctional cells. It is a physio-logic process whereby the body disposes of.


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Apoptosis in cardiac biology Download PDF EPUB FB2

Apoptosis in Cardiac Biology, written by a team of internationally renowned researchers, gives a timely synopsis of basic mechanisms, cellular and structural targets and, finally, clinical implications of programmed cell death in the heart.

The expert authors of this volume give concise overviews on general and cell-specific aspects of programmed cell death in cardiac myocytes and fibroblasts, as well as in Format: Hardcover. Apoptosis in Cardiac Biology, written by a team of internationally renowned researchers, gives a timely synopsis of basic mechanisms, cellular and structural targets and, finally, clinical implications of programmed cell death in the heart.

The expert authors of this volume give concise overviews on general and cell-specific aspects of programmed cell death in cardiac myocytes and fibroblasts, as well as in. Apoptosis in Cardiac Biology, written by a team of internationally renowned researchers, gives a timely synopsis of basic mechanisms, cellular and structural targets and, finally, clinical implications of programmed cell death in the heart.

Apoptosis in Cardiac Biology, written by a team of internationally renowned researchers, gives a timely synopsis of basic mechanisms, cellular and structural targets and, finally, clinical implications of programmed cell death in the heart.

The expert authors of this volume give concise overviews on general and cell-specific aspects of programmed cell death in cardiac myocytes and fibroblasts, as well as in Brand: Springer US.

COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

As summarized in this volume, most if not all cardiac cell types entertain the complex machinery of programmed cell death. Specifically, histochemical and molecular studies document beyond any doubt that cardiac myocytes, endothelial as well as vascular smooth muscle cells may undergo : Heribert Schunkert.

The book is written primarily for basic science and clinical researchers (graduate students, postdoctoral fellows, scientists). Biomedical researchers working in radiation biology, pharmacology, and molecular pathology also will value this book because of its focus on apoptosis in various organs including the heart and brain.

Cardiocyte apoptosis, a morphologically different mode of cell death from necrosis, is an important component of the remodeling process and of the transition from an adaptive myocardial condition to end-stage cardiac failure (Figs.

1 and and2). Cardiac apoptosis is a genetically programmed and energy-requiring process that is executed by a family of ubiquitously expressed cysteine proteases Cited by:   Inhibition of Apoptosis as Therapy for Cardiovascular Disease.

Since apoptosis is implicated in the pathogenesis of many different cardiovascular diseases, the inhibition of apoptosis promises to be an extraordinarily important target for therapeutic by:   Apoptosis provides a current and comprehensive collection of methods for the study of cell death.

Using a diverse range of technical approaches and model systems, the chapters in this volume cover topics from the cellular Book Edition: 1. Apoptosis (type I programmed cell death) of cardiomyocytes is a major process that plays a role in the progression of heart failure.

The early response gene IER3 regulates apoptosis in a wide. Apoptotic nucleus (tem) This second lecture will focus upon programmed cell death, known as apoptosis. The previous lecture Cell Death 1 looked at mainly stress and pathological processes.

This single term "apoptosis" describes the way in which the majority of cells within our body are removed every day. Apoptosis and Autoimmune Disease 3. Ischemic Neuronal Death is NOT by Classic Apoptosis Role of Caspases in Apoptosis in Vitro Studied by Gene Targeting 5.

Why Artherosclerotic Vessels Narrow and Re-narrow 6. Death-associated Proteins 7. Abortive Apoptosis as a Mechanism for Resistance to Cancer Therapy 8. Apoptosis in Cardiac Diseases 9. Apoptosis is a form of programmed cell death, or “cellular suicide.” It is different from necrosis, in which cells die due to injury.

Apoptosis is an orderly process in which the cell’s contents are packaged into small packets of membrane for “garbage collection” by immune cells. Apoptosis and Ischemia/Reperfusion Cardiac Damage As described earlier, apoptosis is a highly regulated, energy-requiring process that follows well-defined time.

proliferation and apoptosis. In the heart, clear evidence points toward focal apoptosis as a contributor to development of the embryonic outflow tract, cardiac valves, conducting system, and the developing coronary vasculature. Systems Biology of Apoptosis summarizes all current achievements in this emerging field.

Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration.

"This is an important publication for researchers on the fringes of the cell death field, or anyone who wants a more global perspective on apoptosis.

The book covers research from chemistry, biochemistry, cell biology, developmental biology, neurobiology, immunology, and cancer biology, and is able to explain complex experiments in an 5/5(2).

Apoptosis has recently been shown to play a major role in cardiac disease (Gill et al., ). Adult cardiomyocytes are terminally differentiated, so cell loss is detrimental to cardiac function. Adult cardiomyocytes are terminally differentiated, so cell loss is detrimental to cardiac by: Apoptosis, a physiological program of cellular death, may contribute to many cardiac disorders [9,10].Apoptosis has been reported to contribute to the loss of cardiomyocytes in cardiomyopathy, and is recognized as a predictor of adverse outcomes in patients with cardiac diseases or heart failure [].Consequently, the interruption of apoptotic pathways could allow development of novel strategies Cited by:.

The significance of apoptosis The development and maintenance of multicellular biological systems depends on a sophisticated interplay between the cells forming the organism, it sometimes even seems to involve an altruistic death also might play a role in plant biology [Solomon, ], and apoptosis .Apoptosis is a key pathologic feature in acute myocardial infarction and heart failure.

Experimental animal studies have shown beneficial effects of inhibiting apoptosis. Understanding the mechanisms involved in the apoptotic cascade may be useful in better understanding of heart failure and its by: In the heart, a tissue rich in mitochondria, the mitochondrial phospholipids provide for diverse roles in the regulation of various mitochondrial processes including apoptosis, electron transport, and mitochondrial lipid and protein by: